SILENCING OF PARP2 BLOCKS AUTOPHAGIC DEGRADATION

Silencing of PARP2 Blocks Autophagic Degradation

Poly(ADP-Ribose) polymerases (PARPs) are enzymes that metabolize NAD+.PARP1 and PARP10 were previously implicated in the regulation of autophagy.Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which PARP2 is silenced by shRNA.The cytosolic electron-dense bodies resemble autophagic vesicles and, i

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Innovative work behavior in high-tech enterprises: Chain intermediary effect of psychological safety and knowledge sharing

This study aims to explore the relationship between organizational innovation climate (OIC) and innovative work behavior (IWB), using psychological safety (PS) and knowledge sharing (KS) as mediating variables.Based on the social cognitive theory (SCT), this study proposes a conceptual framework to explore innovative work behavior.The structural mo

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